What is erythropoietin?
The common name
for erythropoietin is
epogen,
or EPO for short.
EPO is a human drug, a synthesized hormone, which increases the production
of red blood cells in people or animals. Darbepoietin, also known as
Aranesp, is a similar drug. There is no reason to administer EPO or
Aranesp to a horse. They are for humans who have anemia, cancer, or
Acquired Immune Deficiency Syndrome (AIDS). EPO and Aranesp are
prohibited substances for racing in many jurisdictions around the world.
In September 2002 the Kentucky Racing Commission added EPO to its list of
banned substances. Texas, Louisiana, Delaware, California, Illinois,
Florida, New Jersey and New York have moved forward with testing for EPO
antibodies as well, some before Kentucky, and some after.
So what is all the fuss about?
Let's just say it is strongly suspected
that EPO is being administered to races horses and has been for ten years
or more beginning in the mid 1990s. The use of EPO is generally
suspected of the less reputable practitioners in the sport. By no
means are the vast majority of trainers guilty. But there are a few
who taint the sport with use of banned substances, including EPO.
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What happens to a horse
getting EPO?
Think about what
happens to a horse when he gets EPO injections over a period of eight to
twelve weeks. Every day his body produces more and more red blood
cells. Red blood cells are the key building blocks to endurance for
athletes. And there is no finer athlete than the thoroughbred
racehorse. Red blood cells are tiny oxygen-generating machines.
The more red blood cells a horse has flowing through his veins, the more
oxygen he can produce during his training, and of course during a race.
The more oxygen that is released to his muscles, the longer he can operate
at maximum efficiency. This is a great advantage in a horse race,
particularly in a grueling route race.
A good horse getting EPO can be transformed into a great
horse under the proper care. He can compete with other horses that
were once his superior, and he can dominate horses which were once his
equal.
Is there any danger to the
horse?
There is a problem with prolonged administration
of EPO. Over time, EPO "turns blood turns into sludge." Red
blood cells add thickness to blood, and an unnatural concentration of red
blood cells can lead to a dangerous thickening of the blood. This
dramatically increases the risk of heart failure, laminitis, blood clots,
and a host of other debilitating conditions. There can be no doubt
as to the seriousness of the threat to the health and well-being of
innocent racehorses. And, of course, this is all done in homage to
the mighty dollar.
Is there a way to detect EPO?
This a very
tricky area in which to maneuver. In fact, EPO occurs naturally in
humans and horses. There is a test to detect the antibodies
to erythropoietin (EPO). This is one of the Enzyme-Linked
ImmunoSorbent Assay (ELISA) tests. There is not, however, a test to
definitively detect the presence of abnormal concentrations of EPO itself.
The implications are far-reaching.
Racing commissions require that a banned substance be identified in the
bloodstream of a horse in order to register a violation against the
trainer. There is no such analog for the discovery of the
antibodies of a banned substance. In this case, the owner and
trainer of the horse which tested positive for EPO antibodies are
notified, and asked not to race the horse until the connections submit a
"clean" test with no evidence of EPO antibodies in the bloodstream.
No penalties are assigned,
though, because EPO antibodies can remain in the horse's bloodstream as
long as 120 days. It is, therefore, impossible to pinpoint who
applied the EPO and when. The EPO may not have been administered by
the horse's current connections at all, although it may be likely.
There is hope for a new test to detect the presence of EPO. It
focuses on detecting plasma transferrin receptor activity, which occurs
within hours after administration of EPO. If the new test is
perfected, it can be used to hold violators accountable if a horse
receives the drug on their watch.
What is a "milkshake"?
"Milkshakes" are
on the list of banned substances
for race tracks.
Milkshake is backstretch slang for a mixture of bicarbonate soda and a
liquid force-fed to a horse before it competes. The "milkshake"
serves as an alkalizing agent to neutralize the lactic acid produced in
the muscles of a fully extended horse. It is commonly known that the
"burn" in an athlete's muscles after prolonged exertion emanates from
lactic acid, a substance naturally produced by the body. It is
thought that lactic acid is part of the body's natural warning system to
cease exercising the overworked muscles before permanent damage results.
The milkshake serves to neutralize the lactic acid, which in effect
neutralizes the defense system of the body. The horse will continue
to run hard long after his pain threshold has been reached. The
muscles continue to work hard longer, and a horse can run faster for
longer this way. And a horse can break down this way as well,
because the warning signals from the body are being effectively masked by
the milkshake.
Is there a way to detect
milkshakes?
An effective test has been
developed to detect the administration of milkshakes. Blood samples
are taken pre-race and post-race in order to measure the level of carbon
dioxide present in the bloodstream of the horse. If the
concentration exceeds the threshold reading of 37 millimoles per liter of
blood, a violation is declared. Harness racing has been testing for
milkshakes since the 1990s. Major thoroughbred tracks and racing
jurisdictions have only recently made such testing a priority.
What about anabolic steroids?
Anabolic steroids have been used on some horses in order to develop
muscle strength and an aggressive stance towards competition.
Testing has existed for some time to detect the presence of anabolic
steroids, but only recently has the racing industry taken a firm stance
on enforcing policy.
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What is the good news?
The good news is that major thoroughbred
tracks and racing jurisdictions are taking the threat of performance
enhancing drugs seriously. Testing has improved dramatically in
recent years and so has the attitude of the state racing commissions.
Without proper enforcement of the banned substance policies the sport will
implode and be rejected by the fans that still remain.
We must hope that the future is bright for the world of thoroughbred
racing that we all love. But as fans we must remain vigilant and
allow no free rides for violators of the banned substance policies in any
state hosting thoroughbred racing.
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